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KMID : 0613820110210070997
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Journal of Life Science
2011 Volume.21 No. 7 p.997 ~ p.1003
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Change of Mitochondrial Biogenesis Genes on Regular Exercise Training in Adipocytes of Ovariectomized Rats Fed on High Fat Diet
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Lee Jin
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Abstract
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Menopause and obesity are associated with metabolism. The purpose of this study was to examine the changes of PPARγ, PGC-1(α, β), NRf-1 and TFAM mRNA and mitochondria biogenesis in adipocytes and investigate the effect of swimming exercise for 6weeks on ovariectomized rats. Rats were randomly assigned to 3 groups: (1) ovariectomized rats fed with a control diet (C, n=4), (2) ovariectomized rats fed with high fat diet (H, n=4), and (3) ovariectomized rats trained to exercise and fed with high fat diet (H+EX, n=4). Exercise was performed by swimming for 5 days/wk, with a progressive increase in exercise over the course of 6 weeks. Results showed that the fat tissue weight in the H group was markedly increased (p＜0.01) compared to other groups, however, regular exercise significantly decreased fat weight. The PPAR-γ (p＜0.05), PGC-1α (p＜0.01), -1β (p＜0.05), NRf-1 (p＜0.01) and TFAM (p＜0.05) mRNA expression in the adipocytes of H+EX were higher than in the H group. These results suggest that regular exercise for 6 weeks might exert positive effects by increasing PPAR-γ, PGC-1 (α, β), NRf-1 and TFAM mRNA expression and mitochondria in adipocytes. Thus, regular exercise may be helpful in the improvement of mitochondria biogenesis function in obese, ovariectomized rats.
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KEYWORD
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Ovariectomized rats, obesity, exercise, PPPAR-γ, PGC-1(α, β), mtTFA, NRf-1, mitochondria
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